Zollinger-Ellison syndrome is also called gastrinoma. It consists of upper GI tract ulcers, increase in the amount of gastric acid production and tumors of the pancreas which do not involve those cells which produce insulin. The tumors produce gastrin, which is responsible for the syndrome. It is not rare for this disorder to occur with tumors of other glands of the body. The condition, multiple endocrine neoplasia 1, is a hereditary disorder.
Causes of Zollinger-ellison Syndrome
Tumors of the pancreas cells that produce gastrin are the cause of Zollinger-Ellison syndrome. Occasionally, these tumors can be found in the lining of the small intestine. The tumors are frequently multiple.
Signs and Symptoms of Zollinger-ellison Syndrome
The initial onset of symptoms from Zollinger-Ellison syndrome in usually between 30 and 60 years of age. Upper abdominal pain is present. The pain may spread to the back. Diarrhea commonly occurs. Foul smelling urine is common. Perforation of the stomach or upper intestine can lead to vomiting blood or black, tarry stools. Blood loss can lead to anemia with shortness of breath, fatigue and rapid or irregular heart beat.
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Medical Content Last Updated on 07/12/2008
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