Drug induced hepatitis occurs when certain drugs produce some level of toxicity to the cells of the liver. The disorder may occur due to high levels of certain drugs or may develop in reaction to a small quantity of a specific compound.
Causes of Drug Induced Hepatitis
High doses of certain compounds, such as vitamin A, niacin and alcohol, can lead to drug induced hepatitis. Other drugs may cause it due to a reaction that can occur with low levels of the compounds. Examples of these are phenothiazines, monoamine oxidase inhibitors, indomethicin, oral contraceptives, INH, tegretol, and dilantin.
Signs and Symptoms of Drug Induced Hepatitis
Symptoms include malaise, fatigue, loss of appetite, and nausea. There is frequently pain and tenderness in the right upper abdomen. Jaundice - yellowing of the skin and eyes - may occur to varying degrees.
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Medical Content Last Updated on 07/12/2008
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