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Drug Induced Coagulation Disorders


Overview of Drug Induced Coagulation Disorders

overview

Certain drugs can damage cellular elements of the blood or the cells being produced in the bone marrow. They can also interfere with the normal function of the clotting proteins. The end result of any of these problems is a decrease in the number or function of a specific component of the blood stream or impairment of the clotting proteins. The clinical results depend on which element is affected.

Causes of Drug Induced Coagulation Disorders

causes

Drugs interfere with coagulation by damaging or destroying platelets. They can also have a direct affect on the bone marrow, where production of platelets as well as other cellular elements of the blood is affected. This can occur with chemotherapeutic drugs, certain antibiotics and certain anticonvulsants, to name a few. Other drugs, such as coumadin or heparin, interfere with the normal function of the clotting proteins. there are often used to prevent clotting in certain clinical diseases, such as stroke or pulmonary embolism.

Signs and Symptoms of Drug Induced Coagulation Disorders

signs and symptoms

Bleeding and easy bruising are common. Blood in the stool or urine can occur. Recurrent nose bleeds are also common manifestations of impaired coagulation. Excessive bleeding during surgery and excessive menstrual bleeding can also occur.



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Medical Content Last Updated on 07/12/2008

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