Fibrous dysplasia occurs when areas of bone are gradually replaced by abnormal tissue. The bone marrow becomes filled with this abnormal tissue. Consequently the bones appear larger and become heavier. The disorder may be limited to a single bone or may occur widely through the skeleton. The severe form of the disorder is usually evident in childhood. When only a single bone is involved, it often is not diagnosed until early adulthood. Hyperpituitarism, hyperthyroidism, and Cushing's syndrome are often seen in conjunction with fibrous dysplasia. Occasionally girls with fibrous dysplasia will have the early onset of secondary sex varcharacteristics. There is no cure for fibrous dysplasia.
Causes of Fibrous Dysplasia
The cause of fibrous dysplasia is unknown.
Signs and Symptoms of Fibrous Dysplasia
The most common symptom is bone pain, usually occurring in the ribs, facial bones or lower legs. Abnormal skin discoloration may occur. The bones which are involved may become deformed. In addition, they become weak, and unexpected fractures may occur. In young girls, secondary sexual varcharacteristics may develop at a very young age.
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Medical Content Last Updated on 07/12/2008
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