Gilbert's syndrome results in increased blood levels of bilirubin which is a yellow chemical by-product of red-blood-cell breakdown. This is not a disease. It is a normal variant and is usually found with routine testing. It is more common in men, but can affects both sexes. Symptoms may not be apparent until ages 20-40, but are present from birth.
Causes of Gilbert's Syndrome
Due to some mild genetic abnormalities the liver is less effective than normally in changing bilirubin to bile. This causes abnormal high levels of bilirubin in the blood. When the bilirubin level is high enough, jaundice - yellowing of the skin and eyes, may appear. If there are any liver abnormalities associated with this disorder, they are minor.
Signs and Symptoms of Gilbert's Syndrome
Gilbert's syndrome typically does not produce any symptoms. When symptoms do occur, they consist primarily of jaundice - yellowing of the skin and eyes. Occasionally, people with this disorder will complain of tiredness, appetite loss, or upper abdominal discomfort.
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Medical Content Last Updated on 07/12/2008
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