This disorder represents somewhat of an overlap between Rheumatoid arthritis, systemic lupus erythematosis and polymyositis. It most frequently begins in the twenties or thirties. Women are affected more commonly than men.
Causes of Mixed Connective Tissue Disease
This is an autoimmune disorder. It has features common to SLE. RA, polymyositis and scleroderma.
Signs and Symptoms of Mixed Connective Tissue Disease
Raynaud's phenomenon is a common symptom of this disorder. Here, there are changes in the color of the skin, particularly of the hands, when exposed to cold. Puffy hands, joint pain and muscle pain occur. Fever may develop. Eventually, there may be tight, shiny skin, particularly of the hands and feet. A rash may develop on the face and there may be increased sensitivity to the sunlight. Hair loss and ulcerations of the mouth may occur. Joint pain may become associated with joint stiffness and swelling. Deformity of the joints may occur. The muscles may become weakened, particularly those around the shoulders and hips. Chest pain and shortness of breath may develop. Difficult or painful swallowing may develop as well as acid reflux.
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Medical Content Last Updated on 07/12/2008
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