Under normal conditions, the hypothalamus controls the degree of reabsorption of water from the kidney by altering the secretion of antidiuretic hormone. Certain genetic disorders leads to alterations in the receptors for vasopressin, or antidiuretic hormone, in the kidney. The compound cannot carry out its normal role, and excess water is excreted by the kidneys. This can lead to dehydration and alteration of electrolytes within the body.
Causes of Nephrogenic Diabetes Insipidus
The main cause of Nephrogenic diabetes insipidus is a genetic mutation that leads to alteration in the receptors within the kidney. They cannot respond adequately to antidiuretic hormone. Sometimes, they do not respond at all. The mutation can occur on either the sex chromosome, or X chromosome. It can also occur on the other chromosomes.
Signs and Symptoms of Nephrogenic Diabetes Insipidus
Increased urination and increased thirst are the hallmarks of both Nephrogenic diabetes insipidus and Diabetes insipidus. When the individual is unable to replenish the excess fluid that is urinated, dehydration will occur. This can lead to weakness, rapid heart rate, confusion, coma and death.
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Medical Content Last Updated on 07/12/2008
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