Almost 10% of patients with advanced forms of cancer will develop elevated levels of calcium, or hypercalcemia. The cancers which are most commonly seen in associated with this disorder include: lung, breast, head and neck, kidney and multiple myeloma. In addition to the changes which may occur in the bones, the kidney probably plays an important role is reabsorption of calcium in these disorders.
Causes of Hypercalcemia Secondary To Cancer
Increased release of calcium from bone is the key explanation for the development of hypercalcemia in these cases. Bone resorption is increased. Parathyroid hormone, which is integral to the maintenance of normal bone metabolism is also involved. Elevated levels of this hormone, produced by tumors, can lead to increased calcium conservation by the kidney. Metastatic lesions of the bones have though to increase the release of calcium through the stimulation of osteoclasts and bone destruction.
Signs and Symptoms of Hypercalcemia Secondary To Cancer
Hypercalcemia produces fatigue, anorexia, nausea and vomiting. In addition, there is increased thirst, constipation and muscle weakness.
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Medical Content Last Updated on 07/12/2008
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